GENETEX WEBINAR SERIES 2022
RAS genes in development and cancer
by Matthias Drosten, Ph.D.,
Group Leader, Centro de Investigación del Cáncer (CIC-IBMCC), Salamanca, Spain
RAS genes have gained prominence due to their implication in human cancer. Mammals harbor three RAS loci (HRAS, NRAS, and KRAS) that are found mutated in many different tumor types, albeit with clear tissue-selective preferences for individual RAS loci. Moreover, whereas HRAS and NRAS produce only one major protein, the KRAS locus gives rise to two different protein isoforms via alternative splicing of the final exon. Thus, all four RAS proteins differ in the C-terminal hypervariable region that determines how RAS proteins are anchored to the cell membrane. Despite these differences, RAS proteins share common biochemical features and participate in similar activities. In his webinar, Dr. Drosten will focus on three fundamental aspects of RAS biology: (1) What is the biological difference between the three RAS genes and what is their role in normal homeostasis? (2) What is the (differential) role of RAS paralogs in cancer? (3) What are the contributions of each of the KRAS isoforms to development and cancer? He will explain how mouse models have been crucial in revising some of the classical concepts of RAS biology.
When: Wednesday, October 5, 2022, at 4:00 pm (CEST)