Focus List

GENETEX: SARS-CoV-2 Omicron therapeutics



SARS-CoV-2 Omicron therapeutics: Getting to know the unknown and the road ahead

by François Jean, Ph.D. - Professor of Virology, University of British Columbia.
Lead, Pillar 10, Antiviral strategies & antiviral therapeutics, Coronavirus Variants Rapid Response Network (CoVaRR-Net) Founder, UBC CL3 Facility for Infectious Disease and Epidemic Research (FINDER) 

As SARS-CoV-2 Omicron variants continue to dominate around the world and accumulate novel mutations leading to immune evasion, antiviral treatments are becoming increasingly important to limit hospitalizations and death due to COVID-19. Studies are still lacking to understand which combination therapy approaches will have the greatest potency and synergy against SARS-CoV-2 Omicron sub-variants. Dr. Jean will present the recent discovery of novel pan-coronavirus antiviral drugs directed at viral and host-cell enzymes. He will discuss their applications as direct-acting antivirals (DAAs) and host-directed antivirals (HDAs) against SARS-CoV-2 Omicron variants when used alone or in combination in 2D and 3D cell-based systems of viral infection. This work will provide new insights into the unique biology of SARS-CoV-2 Omicron variants, and unravel potential combination antiviral therapies based on HDAs and DAAs acting synergistically as alternatives to monotherapy to improve COVID-19 treatment.

When: Wednesday, February 22, 2023, at 5:30 pm (CET)


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